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RUO - FP308 Chromosome 10 centromere probe reagent

Cat.# FP-308: Chromosome 10 Centromere Probe Reagent


[Overview]

Chromosome 10 deletion is a chromosome abnormality that occurs when there is a missing copy of genetic material on the long arm (q) or short arm (p) of chromosome 10. The severity and the signs and symptoms depend on the size and location of the deletion, and which genes are involved. Features may affect many parts of the body and may include low birth weight, growth delay, developmental delay, low muscle tone (hypotonia), and communication difficulties. Birth defects, various medical problems, and/or distinctive facial features may also be present.


Detailed Description:

This Fluorescence In Situ Hybridization (FISH) probe reagent is designed to specifically target the centromeric region of chromosome 10 (CEP 10). It is formulated for the qualitative enumeration of chromosome 10 copies in human metaphase chromosome and interphase nucleus preparations derived from research samples.

 

Intended Use:

This product is For Research Use Only. It is not intended for diagnostic, prognostic, or therapeutic use.

This probe serves as an essential tool for fundamental cytogenetic research, allowing investigators to:

1. Analyze numerical abnormalities (aneuploidy) of chromosome 10 in various in vitro research models.

2. Investigate the significance of chromosome 10 copy number variations in cellular processes and disease pathogenesis.

Employ as an internal control probe in multi-target FISH assays for studying complex genomic instability, such as in the analysis of glioblastoma multiform for research purposes.



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